What is nociplastic pain?
Nociplastic pain is the semantic term suggested by the international community of pain researchers to describe a third category of pain that is mechanistically distinct from nociceptive pain, which is caused by ongoing inflammation and damage of tissues, and neuropathic pain, which is caused by nerve damage.
What causes nociplastic pain?
The mechanisms that underlie this type of pain are not entirely understood, but it is thought that they involve pain creation or augmentation by the central nervous system through pathways that involve predictive processing, threat conditioning, sensory processing and altered pain modulation.
How does nociplastic pain present?
The symptoms observed in nociplastic pain include multifocal pain that is more widespread or intense, or both, than would be expected given the amount of identifiable tissue or nerve damage, as well as other CNS-derived symptoms, such as fatigue, sleep, memory, and mood problems.
This type of pain can occur in isolation, as often occurs in conditions such as fibromyalgia or tension-type headache, or as part of a mixed-pain state in combination with ongoing nociceptive or neuropathic pain, as might occur in chronic low back pain.
Like any other kind of pain, it is always and absolutely real, it is never imagined.
The amazing thing about nociplastic persistent pain is that can be reversed, or unlearned. Read the following entries of the blog to learn more.
What are other terms for nociplastic pain?
Because the term nociplastic alludes to underlying mechanisms and points to effective treatments that can bring about neural repatterning, it is my preferred term.
For epidemiological and descriptive / classification purposes, the term primary pain, used in the World Health Organization’s International Classification of Diseases (ICD-11) can be used as well, though it doesn’t point to the underlying mechanisms or effective treatments.
For some symptoms or diagnoses alluding to the function of certain organs or systems, some providers, including myself, may use “functional symptoms / syndrome” (e.g. functional neurological symptoms like non-epileptic seizures, or functional digestive symptoms such as irritable bowel syndrome).
You might also have encountered the following terms: psychophysiologic pain, psychosomatic symptoms, mind-body syndrome, TMS (tension myositis syndrome or tension myoneural syndrome), FND (functional neurological disorder), central sensitization syndromes, and more.
If we work together, we will start from whatever language makes sense to you, while at the same time engaging in an exploration of whether this language elicits an experience of safety, validation, and possibilities for healing, and whether it enables expanding and deepening your understanding of the many threads at play in your lived experience. And if you feel like you’d like to explore new language that will evoke the felt sense and healing you want to cultivate and grow, we’ll do that. Let’s make sense of your experience, and the best language to support your healing, together.
If you’d like to learn more about whether there is a nociplastic element to your pain or symptoms, read the next entry, or check out this questionnaire.
Ready to be supported on your path to healing and recovery?
About the author:
Dr. Lilia Graue is a physician, psychotherapist, and mindbody healing mentor.
After living with chronic pain for more than a decade, she found freedom through an integrative mindbody approach grounded in neuroscience, mindfulness, and compassion.
She is passionate about helping people who are living with chronic pain, fatigue, long COVID, and other persistent symptoms to find freedom and reconnect with joy, vitality, purpose, and agency. She also loves mentoring fellow practitioners—therapists, coaches, and clinicians— to support them in creating trauma-integrative, relational, and sustainable healing spaces, while keeping their sanity and their passion and thriving personally.
With over 25 years of experience in medicine and psychotherapy, Lilia’s work prioritizes consent, curiosity, and co-creation, honoring individual context, systemic influences, and the power of genuine relationship in supporting long-term change and healing. She works with people globally in both English and Spanish.
Originally from Mexico City, she currently lives in London with her husband and the two rescue cats who own them, Ziggy and Lupito. In addition to her work, she loves spending time in nature, baking, reading, traveling, and enjoying live music.
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